SAINT probability scoring of the proteomics data for NLRP3-APEX2 compared to the negative bead control. Proteins passing the cutoff (SAINT probability score >= 0.8 and FC-A score >= 1) are considered high-confidence proximal proteins for NLRP3. Previously reported NLRP3-interacting proteins (BioGRID, v.4.4.213) are colored purple. All other proteins are shown in gray. Inactive (PDB:6NPY) and active NLRP3 (PDB:8EJ4) are shown as surface view with a model.
