Representative images showing location and level of fluorescent tracers within the brain 30 min following injection into CSF (intra cisterna magna [i.c.m.] A647-ovalbumin, under ketamine/xylazine anesthesia) or blood (i.v. FITC-albumin) in naive mice, mice with ECM (RMCBS 11–12) and mice 18–24 h after treatment with artesunate.