DSS ± IL-22.Fc (10 ng/mL)-treated colon organoid of Math1-PGR lineage tracer mice on day 9 post-passage with the organoid area on the right (150 μm). Green organoids represent MATH1+progenitor cell-mediated regeneration after DSS treatment. Data are presented as mean ± SEM.****p< 0.0001 (Mann-Whitney test, two-tailed).