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Next, the primed SNARE-synaptotagmin-complexin complex forms,7,8although the transition to this complex can be inhibited by α-SNAP. In the presence of MUN, α-SNAP remains present and inhibits vesicle fusion, while the longer C1C2BMUNC2C fragment of Munc13 may permit the clearance of α-SNAP and leads to the fusion-competent SNARE-synaptotagmin-complexin complex.
#Workflow#Illustration#SNARE-Synaptotagmin-Complexin Complex#Alpha-SNAP#MUN#Vesicle Fusion#C1C2BMUNC2C Fragment#Munc13#Fusion-competent SNARE-synaptotagmin-complexin complex
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