Error Bar Plot from Scientific Research

We estimated the indirect protection from a variant-targeting vaccine (bivalent vaccine formulated with ancestral strain and Omicron subvariants BA.4/5 to target circulating variants) in California state prisons. Our goal was to determine how concordance of COVID-19 vaccine formulation and circulating SARS-CoV-2 variants affects vaccine-derived indirect protection. Administration of bivalent vaccines began in September 2022, which yielded approximately three months of follow up; therefore, estimates were only available for three months. We include estimates of indirect protection from ancestral monovalent vaccines during the study period prior to bivalent vaccine introduction. The average time since bivalent vaccine was more recent than average time since last monovalent vaccine (within three months; Supplementary Table 11 ). We estimated indirect protection and plotted the mean (point estimate) and associated 95% confidence intervals (bars) for indirect protection.

DOI