Kinase networks inferred from kinase-substrate relationships derived from kinase recognition motifs and phosphoproteomic profiles during differentiation. The width of edges between kinases indicates the correlation in their kinase-substrate profiles. The outer ring shows the level of regulation of the respective kinases across time compared to 0 h using a two-sided Wilcoxon rank-sum test. An asterisk (*) denotes those that are significantly regulated at four or more time points.
