Representative images (F) and quantification (G) show that both PTEN+RPTOR and PTEN+RICTOR double mutants normalize the overgrowth of PTENmutant human cortical organoids at 4 weeks. Scale bar, 500 μm. Each data point represents an organoid (n= 23–69 for each group from 3 independent experiments).pvalues are calculated using post hoc multiple comparison after ANOVA.
