Heatmap from Scientific Research

DNA repair genes and ATXN expression was measured by real-time qPCR and plotted in a heatmap alongside EI on the left. For each disease, the corresponding ATXN was analyzed (ATXN1 for SCA1, ATXN2 for SCA2, ATXN3 for SCA3, ATXN7 for SCA7). Brain regions were grouped as follows: basal ganglia and related structures (amygdala, caudate, pallidum, thalamus), blood, cerebellum, fetus, cortex (frontal cortex, motor cortex, visual cortex), and brainstem (midbrain, substantia nigra, pons, olive, medulla oblongata). For visualization, the qPCR values were scaled to zero mean and unit variance (relative values from 4 to -4). SCA1:n= 1 (cerebellum:n= 3), SCA2:n= 1, SCA3:n= 3, SCA7:n= 2.

DOI