Receptor ligand analysis of spatial and cell type distribution of CXCL11-CXCR3 signaling. Circos plots showing source (ligand) and target (receptor) expressing cell populations in CPI-colitis samples. Coord width is scaled to expression level. scRNA-seq populations are abbreviated as follows: Gli, glial cells; GD,gamma-delta cells; F-Ef., FGFBP2+effector T cells; Ent, enterocytes; End, endothelial; Cyc, cycling cells; Exh CD8+HAVCR2+T cells; B, B cells; Z-683+- CD103+ZNF683+; S3/S4, stromal 3 & 4; S2, stromal 2; S1, stromal 1; Gob, goblets; Per, pericytes; Nv CD8, naive CD8+T cells; Nv, naive CD4+T cells; MF, myofibroblasts; MYL, myeloid cells; IFN-R, interferon response B cells; G-Ef1, GZMK+effector T cells; G-Ef2, GZMH+effector T cells; CT-E, crypt top enterocytes; TAs, transit amplifying epithelium; PL, plasma cells; EEC, enteroendocrine cells; Abs and Abs2, absorptive epithelial cells 1 and 2.
