Analysis of the association between recurrent mutations (in at least five tumors) and AC-like differentiation scores, for oligodendroglioma tumors of grade 2 (left) and of grade 3 (right) reveals a significant association (FDR-adjusted p value = 0.02, Wilcoxon rank-sum test) between mutations inNOTCH1and low degree of AC-like differentiation in grade 2 lesions (11/72 samples) but not in grade 3 lesions (16/62 samples). Each panel shows the difference in average AC-like differentiation score between tumors with and those without a specific mutation (X axis), and the significance of that score (Y axis, defined by -log10 of the p value calculated by t test and corrected for multiple testing by the Benjamini-Hochberg method). Horizontal line shows a significance threshold (FDR = 0.05), highlightingNOTCH1in grade 2 oligodendroglioma as the only significant association; Vertical line represents the mean AC-like differentiation score.
