Microscopy from Scientific Research

Depletion of the tRNAIle(TAT) pool in the context of Gtpbp2 loss causes cerebellar granule cell degeneration. (E) Hematoxylin and eosin-stained (H&E) sagittal sections of cerebella from 12-week-old mice except Gtpbp2−/−;tRNA-Arg-TCT-4-1B6J/B6J (Gtpbp2−/−, n-Tr20J/J), which is shown at 8 weeks. Lower panels are higher-magnification images of lobule III (black rectangle in wild-type). Scale bars, 1 mm (top panel), 50 μm (bottom panel). Cerebellar lobules are indicated by Roman numerals.

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