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B. thailandensis senses the membrane protrusion and fires T6SS-5 (light and dark green tube) before the protrusion collapses and is detached from the host cell. The double membrane protrusion is lysed in a way that avoids the exposure of -galactosides (yellow) to galectin-3 (green hexagons), thus avoiding host cell recognition. Dynamin-2 then binds to the membrane remnants and actin (blue) influx from the new host cell allows the formation of new actin tails. The host cell is unable to repair the damaged membranes, and the membranes fuse leading to MNGC formation.

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