Model showing the role of BAZ2A condensates andMalat1in chromatin regulation of ESCs. BAZ2A condensates are close to H3K27me3 bodies and depend on BAZ2A-TAM domain and active transcription. BAZ2A bodies sequester BAZ2A and limit BAZ2A invasion into chromatin. The model shows how BAZ2ATAMoccupies H3K27me3 chromatin with consequent H3K27me3 reduction and activation of gene expression. On the right, BAZ2A associates withMalat1and chromatin contacting nuclear speckles.Malat1is required for BAZ2A binding to chromatin and counteracts BAZ2A body formation, which do not contact nuclear speckles. Statistical significance in boxplots in (E) and (G) was calculated with Mann-Whitney test (*p < 0.05,**p < 0.01,****p < 0.0001; ns, nonsignificant). Error bars represent SD.
