Model showing BAZ2AWTforming bodies through the TAM domain and the association with chromatin depleted of H3K27me3. The lack of the TAM domain impairs body formation and promotes BAZ2A invasion into H3K27me3 domains and the loss of this repressive signature. Statistical significance in boxplots (G), (I), (K), (M), and (O) was calculated with Mann-Whitney test (∗p < 0.05,∗∗∗∗p < 0.0001). Error bars represent SD.