Model for translation regulation during heat shock. Top: legend for proteins. Bottom: eIF4F, Pab1p, and Ded1p promote translation of housekeeping mRNAs. Upon heat shock, temperature-driven conformational rearrangements in translation factors promote the assembly of translationally silent mRNPs that engender into HSGs. Translation of newly synthesized heat shock mRNAs is promoted by eIF4A.
