Protein Structure from Scientific Research

Comparison of low-resolution cryo-EM reconstructions of YPEL5-bound (left, YPEL5 shown in red) and NMNAT1-bound (middle, fit with crystal structure of NMNAT1 as in Figure 3A, loops highlighted by dotted lines) WDR26-CTLH E3 complex. The overlay of the two maps (right) reveals overlap between YPEL5 and both NMNAT1-binding sites in the opposing WDR26 dimers.

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