Scatter Plot from Scientific Research

Neutralization activities of 09-1B12-UCA, O1, O2, and 09-1B12 across: H3N2 (eight diverse viral strains covering >50 years of diversification: A/Aichi/2/1968, A/Bilthoven/1761/1976 A/Beijing/353/1989, A/Johannesburg/33/1994, A/Brisbane/8/1996, A/Fujian/411/2002, A/Perth/16/2009, A/Switzerland/9715293/2013); H7N9 (A/Shanghai/02/2013); H5N1 (A/Vietnam/1203/2004); and H1N1 (A/California/07/2009). Cross-group protecting VH1-18 QxxV bnAbs neutralize group 2 viruses but show more limited neutralizing activity against group 1 IAV.24,48VRC01 served as an isotype control, 09-1B12 was a positive control for group 2 IAV neutralization, and CR6261 was a positive control for group 1 IAV neutralization. N.N., non-neutralizing (each antibody was run in triplicate, one experiment).

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