Microscopy from Scientific Research

Imaging mass cytometry (IMC) on paraffin-embedded skin biopsy specimens from HDs or healthy skin (HS) and a wart from P2. In the upper panel, the epidermis and dermis were defined based on cytokeratin and E-cadherin expression. The images in the middle panel show the staining for CD3, CD8, CD68, and langerin. Finally, the images in the lower panel show Langerhans cells (LCs), macrophages (Mac), CD4, and CD8 T cells after segmentation and identification by a machine-learning approach.

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