Single-cell RNA sequencing on CD34+-enriched HSPCs from the bone marrow of P2 and two HDs (one male, one female, aged 44 and 53, respectively). Unsupervised analysis of CD34+HSPCs from HDs (HD1: 7,604 cells and HD2: 7,298 cells) and P2 (262 cells), represented as two-dimensional uniform manifold approximation and projection (UMAP) plots. All HSCs, HSC and HSC-enriched; MPP; MLP; ImP1 and ImP2, immature myeloid progenitors; NeutroP, neutrophil progenitor; MonoDCP, monocyte and dendritic cell progenitor; BcellP, B cell progenitor; Cycling_BcellP, cycling B cell progenitors; MEP, megakaryocyte and erythrocyte progenitor; EryP, erythroid progenitor; MkP, megakaryocyte-committed progenitor; EoBasMastP, eosinophil, basophil, and mast cell progenitors; NA, not annotated.
