Protein Structure from Scientific Research

The sensor loop bridging the N348 of one nucleotide binding pocket to F360 of the counterclockwise adjacent pocket changes the conformation between the ATP(γS)- and ADP-bound states. In the ADP state, R349–I353 form a 3 10 helix, but in the ADP·Pi state, this transition is incomplete, making this loop the last structural element to convert after ATP hydrolysis (see the Ramachandran analysis in Extended Data Fig. 7).

DOI