8-to-16-cell transition: (left) cell-cycle length (min) in mouse embryos stained with SPY555-DNA and Sir-actin, or not stained (N= 32 cells,n= 4 embryos). (Middle) Interphase length in mouse and human embryos. (Right) Mitosis length in mouse and human embryos. For all plots center line is mean, error bars are standard error. For (B) statistical significance: t test. Mouse quantification (N= 42 cells,n= 6 embryos), human quantification (N= 24 cells,n= 4 embryos).