3D Molecular Structure from Scientific Research

Upper: Superposition of the experimentally determined Ca 2+ -bound C2B domain of rat synaptotagmin-1 (pdb 1TJX) with the AlphaFold2-predicted C2F domain of human dysferlin (Expasy accession number: O75923). The Ca 2+ binding site is highly conserved in both domains (magnified top view). Lower: The magnification shows the site of the four mutated amino acids in a surface-exposed loop connecting the β-sandwich with the Ca 2+ -binding site of the C2F domain.

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