Heatmap from Scientific Research

Free-energy surface for active nucleoplasmic transport projected against the molecular weight and the unfolding force (characterized by AFM) of the translocating protein. The free-energy difference was calculated as ΔG(M,FU) = -kTln(kI(M,FU)/kIR16), where k I is the import rate for a protein of mass M and an unfolding force of F U , and where the import rate of the R16 monomer k I R16 has been used as reference. The dotted white line separates the regimes where mechanics or mass dominate the kinetics of nuclear import.

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