Scatter Plot from Scientific Research

Observed numbers of high PRS called per condition compared to the expected numbers of high PRS per condition. P values are two-sided P values calculated by simulation to account for the uncertainty in the All of Us (AoU) derived ancestry calibration parameters due to the finite size of the AoU training cohort, and further adjusted for multiple hypothesis testing using the Holm-Sidak procedure. Note not all participants get scored for every condition based on age and sex at birth filters.

DOI