Factorial mixed-effects analyses of covariance models examined the two-way interactions between treatment (drug or placebo) and time (before or after treatment). A one-sided t -contrast examining the hypothesis-consistent interaction (drug slowing progression over time relative to placebo) revealed that treatment with LM11A-31 slowed longitudinal degeneration (left panels) and glucose hypometabolism (right panels) in the drug group (sMRI, n = 127; PET, n = 121) compared to the placebo group (sMRI, n = 66; PET, n = 62). Voxels exhibiting this interaction effect are shown at an uncorrected P < 0.05 threshold (magenta) on a population-specific cortical surface. Left and right hemispheres are in the top and bottom rows, respectively. Brain areas exhibiting hypothesis-inconsistent interaction effects are displayed in Extended Data Fig. 7.
