Box plots showing the change in score between the first and last assessments on the ADAS-Cog-13 (left) and MMSE (right) in the pooled LM11A-31 (teal) and placebo (salmon) groups. Note that y axes are scaled differently in each panel. Horizontal lines on box plots represent the median of the distribution. Notches provide the 95% CIs of the median, which represent the reliability of within-group change. The lower and upper hinges of the box plot correspond to the first and third quartiles of the distribution and the whiskers (vertical lines) extend from the hinge to the largest or smallest value, no further than 1.5 times the interquartile range from the hinge. Differences between the drug and placebo groups were not significant using a two-sided Wilcoxon rank sum test for any cognitive test ( P NTB = 0.185; P ADAS = 0.789; P MMSE = 0.492). Given the exploratory nature of the trial, all P values are uncorrected. ADAS13, ADAS-Cog-13.
