A circos plot displaying chromatin interactions (Ci) and eQTLs for rs11705789 . The outermost layer shows the Manhattan plot with -log 10 (P value) for the G6-associated locus, and SNPs with P < 0.05 are displayed. The LD relationship between rs11705789 and other SNPs is indicated with red (r 2 > 0.8), orange (r 2 > 0.6) and green (r 2 > 0.4) colors. Gray SNPs show minimal LD with r 2 ≤ 0.20. The second circle represents the chromosome ring with coordinates, where the genomic risk locus is highlighted in blue. The third circle shows the same chromosome ring, but with Ci- and eQTL-mapped genes represented by orange and green lines, respectively. Genes mapped by both approaches are colored red.
