Data are estimated mean (CI) changes from the estimated baseline value in eGFR ( a ) and UACR ( b ), analyzed using an MMRM. The change in UACR was analyzed as the estimated mean ratio to baseline; for ease of interpretation, these ratios were converted to relative percentage changes from baseline using the formula (estimated ratio - 1) x 100. Darker lines are used for the larger subgroups. Numbers below the graphs are the number of patients contributing to the analysis. Changes in UACR by baseline UACR subgroup at 208 weeks are not presented because of small patient numbers. a Given gradual entry to the trial across the enrollment period and variable follow-up duration, data at 156 weeks and 208 weeks are sparser compared to previous timepoints.
