Data are the observed (that is, as measured) n (%) of patients experiencing their first occurrence of the main 5-component kidney composite endpoint from the in-trial observation period and the HR, and 95% CI was estimated using a Cox regression model, assessed according to patient baseline characteristics. The symbols are the HRs, and the error bars are the 95% CIs. The main 5-component kidney composite endpoint included death from kidney causes, initiation of chronic kidney replacement therapy (dialysis or transplantation), onset of persistent eGFR <15 ml min -1 1.73 m -2 , persistent >=50% reduction in eGFR compared to baseline or onset of persistent macroalbuminuria. P value for the treatment difference by subgroup. Interaction P values were calculated using the score test. P values are two-sided and were not adjusted for multiplicity. Ischemic or hemorrhagic stroke. A combination of two or more events. CVA, cardiovascular accident; PAD, peripheral artery disease.
