Selected genes and conditions in TP53 LOF background (CDKN2A: WT n = 82, LOF n = 156, P < 1 x 10 -10; CDKN2B: WT n = 103, LOF n = 154, P < 1 x 10 -10; BTG2: WT n = 188, AMP n = 81, P = 5 x 10 -10; MDM2: WT n = 218, AMP n = 43, P = 1; MDM4: WT n = 187, AMP n = 79, P = 6 x 10 -9; n = 20 cell lines were sampled in each bootstrap for all genes). The genes with fewer than 25 cell lines in a given condition are not shown.