Left: bar plots showing that the mean percentage of mCherry-positive cells is restricted after (+DOX) H3K4me3 installation by Prdm9 scFV in the presence or absence of the p300 inhibitor (inh) A485. Con, control. Data are biological triplicates; error bars represent s.d. P values were calculated by two-way ANOVA with Tukey’s correction. Right: relative abundance of the indicated histone modifications after programming H3K4me3 (+DOX) in the presence of A485. n = 3 independent experiments, with significance calculated by two-tailed unpaired t-test.
