Protein Structure from Scientific Research

Amino acids that mutated in this study are indicated (in blue, red and orange for mt1, mt2 and dEZH2, respectively) on the structure of PRC2 (gray) and a substrate nucleosome (DNA in black, H3 histones in magenta and the other histones in pink). The structure was determined in the presence of AEBP2, JARID2 and a monoubiquitinated nucleosome (PDB 6WKR (ref. 25 )), but visible are only determinants that were assayed herein, including the core PRC2 subunits and the mononucleosome. S -Adenosyl-homocysteine (SAH) is in CPK yellow representation.

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