Comparison of the absolute effect sizes for local and distant eQTLs for SNP-associated and CNV-associated eQTLs. P values were determined using a two-sided Wilcoxon rank-sum test. Sample sizes are shown on the plots. The center of the box plots corresponds to the median; the upper and lower bounds correspond to the third and first quartiles. The whiskers extend to the upper and lower bounds 1.5 times the IQR (Supplementary Fig. 7 ).