Genomic profiles in the CTLA4 regulatory region annotated in Fig. 1d. Top, CRISPRi tiling in T conv cells restimulated for 6 h. Middle, ATAC-seq profiles of resting (gray) and stimulated (black) T conv cells. Bottom, H3K27ac profile of T conv cells. Beige columns highlight significant CTLA4 CRISPRi regions (Extended Data Fig. 2d,e and the Methods).
