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Schematic for breeding of N0 founder mice to generate N1 and N1F1 generations with different genotypes for Hoxd13 + 6 G > T (G224V). Checkered texture indicates mosaic pattern of edits in the founder mouse. Light blue shading represents heterozygous mice with one copy of the edit. Dark blue shading represents homozygous mice with two copies of the edit. Percentages of the N1F1 generation indicate the expected (not actual) mendelian frequencies of each genotype.

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