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Schematic overview of the in vitro chemical induction of human adult fibroblasts toward chemically induced pluripotent stem cells (CiPSC). Both the uninduced and intermediate stage II cultures were sequenced by scATAC. 5-azaC, 5-azacytidine; C6NYSA, combination of CHIR99021, 616452, TTNPB, Y27632, SAG and ABT869; hADSC, human adipose stromal cell (mesenchymal stromal cell); HEF, human embryonic fibroblast; JNKIN8, c-Jun N-terminal kinase inhibitor; T5J, tranylcypromine, JNKIN8 and 5-azaC.

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