Box Plot from Scientific Research

Prediction of sample age by DNAm from WGBS data of chemical induction of iPSCs. Chemical reprogramming induces genome-wide demethylation and an increase in DNAm age, as reported previously 31 , whereas the addition of 5-azaC globally reduces DNAm to increase DNAm age. Removal of 5-azaC blocks DNAm age from increasing. Sample numbers of biologically independent samples: n = 4 (uninduced); 2 (C6NYSA); 1 (JNKIN8); 1 (5azaC); 2 (C6NYSA + T5J); and 4 (iPSC/hESC).

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