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Schematic of defining putative counterparts of human clock genomic loci in the Drosophila genome. Human ClockDML falling within ±100 bp of the gene transcription start site (TSS) were defined as Promoter ClockDML. For human genes that simultaneously have a promoter ClockDML and one or more Drosophila ortholog gene(s), we define any Drosophila scATAC peaks falling within ±100 bp of the TSSs of these Drosophila orthologs as putative clock-like genomic loci. These loci were subsequently used for EpiTrace analysis in the Drosophila dataset.

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