ROC curves of TRTpred and four CD8 + TIL tumor-reactive predictive signatures (refs. 8 , 11 , 12 , 14 ) applied to the four datasets: ref. 14 (melanoma, n = 4) ( h ), ref. 12 (lung, n = 4) ( i ), ref. 8 ( n = 1 melanoma, n = 2 breast and n = 12 GI) ( j ) and ref. 11 (GI, n = 5) ( k ). All AUCs are reported in Extended Data Fig. 3e . Pt, patient; TAA, tumor-associated antigen; UMI, unique molecular identifier; PCA, principal component analysis; Mel, melanoma; Pan, pan-cancer.
