Line Plot from Scientific Research

From left to right, the dose response curves for CLK14 following Brigatinib treatment. Binding affinities of Brigatinib and CLK1,2,4 (pKd = log10 Kd ) determined by kinobead assays 10. Schematic representation of the two major transcripts for CLK proteins and how the ratio between the two domains shifts to a 1:1 ratio on CLK inhibition. The triangle represents the N-terminal (N term) domain; the dot represents the kinase domain of the protein. Bar plot showing the ratio of the N term and kinase domain transcripts (determined by RTqPCR) for CLK14 as a function of the dose of Brigatinib.

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