Library 2 Sublibrary B: Analysis of 1,629 constructs with sufficient read coverage, categorized based on whether each contains at least one of three crRNAs that target the MYC promoter, and/or at least one crRNA that targets each of the MYC enhancers. Boxplots summarize cell fitness score distributions (as proxy of MYC expression) of all constructs that fall in each category. Boxplots show median, interquartile range, whiskers indicating 1.5 interquartile range, and are overlaid with individual data points each representing a 6-plex construct.
