Comparison of denAsCas12a-KRAB (D908A/E174R/S542R/K548R) versus multiAsCas12a-KRAB (R1226A/E174R/S542R/K548R) in CRISPRi knockdown of CD81 expression assayed by flow cytometry 10 days after crRNA transduction, using the combinations of MOI for crRNA and protein shown. One biological replicate is shown for each condition; additional replicates shown in Supplementary Fig. 9.