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A model of the determinants of Cas9 scission profile identified using BreakTag. The protospacer sequence, human genetic variation and engineering Cas9 variants can dictate Cas9 scission profile, which is strongly associated with precise and predictable genome editing. ins., insertion.
#Workflow#Illustration#Geo Map#Model#Cas9#Scission Profile#BreakTag#Protospacer Sequence#Genetic Variation#Genome Editing#Cas9 Variants
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