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Left, bilateral expression of Pd CO in substantia nigra pars compacta (SNc) dopaminergic neurons and unilateral light-mediated suppression of their striatal projections would induce an ipsiversive side bias during free locomotion. Right, representative locomotion trajectories of Pd CO mice, over successive 10-min periods before, during and after light delivery (top to bottom). Magenta and black colors depict ipsilateral and contralateral angle trajectory segments, respectively.

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