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Potential roles of PRPF40A in early spliceosome assemblies. PRPF40A role in bridging the branch point region of the intron and the 5splicing site could be important for (1) the intron definition events, when the exon definition cannot happen, like in the microexon regulation (left), (2) reinforcement of the A complex bridging (middle) and/or (3) in those events that happen co-transcriptionally due to its shown interaction with the C-terminal domain of the RNA polymerase II (right).

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