Illustration from Scientific Research

Selectivity mechanisms of WW-containing proteins. The different layers of WW domain specificity towards the recognition of Pro-rich peptides start with the intrinsic preference for certain motifs. The selectivity gets increased with these domains combined in tandems and it is even higher if the domains show interdomain contacts upon binding to the right sequences. Finally, the additional layer of selectivity comes from the role of the regulatory regions nearby the WW domains that are able to compete out those suboptimal binding events.

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