Schematic of a microfluidic device with three chambers. -Syn transmission from chamber 1 (C1) to chamber 2 (C2), to chamber 3 (C3) 14 days -syn PFF treatment in C1. The different combinations of neurons tested in C2, listed as C1-(C2)-C3, are WT-(WT)-WT, WT-( Aplp1 –/– )-WT, WT-( Lag3 –/– )-WT, WT-( Aplp1 –/– / Lag3 –/– )-WT.
