Gel from Scientific Research

Immunoblots of endosomal fractions from WT, Aplp1 –/– , Lag3 –/– , and Aplp1 –/– /Lag3 –/– cortical neurons. Aplp1 –/– / Lag3 –/– significantly decreases (~70%) internalized -syn-biotin PFF compared to WT, Aplp1 –/– , Lag3 –/– , neurons. ( p -values: WT vs. Aplp1 − /− 0.0019, WT vs. Lag3 − /− 0.0039, WT vs. Aplp1 − / − / Lag3 − / − <0.0001, Aplp1 − / − vs. Aplp1 − / − / Lag3 − /− 0.0208, Lag3 − / − vs. Aplp1 − / − / Lag3 − /− 0.0091)

DOI