Model illustrating how Munc13-1 and Munc18-1 can differentially control the cargo release probabilities at the release site by altering the fusion pore size and kinetics. For a – d , n = 7 independent BLMs; three sets of NDs were used. For e–h , n = 4 independent BLMs; two sets of NDs were used. For i–l , n = 3 independent BLMs; two sets of NDs were used. Data are presented as mean ± SEM; Student’s t -test (one-tailed) was performed to compare the two means; n.s. non-significance. Relevant source data are provided in the Source Data file.
