Manhattan plot of GWAS in chromosome 6 on antibody response to first-dose COVID-19 vaccine. SNPs within the MHC region are labelled in red colour, with the nearest gene to the lead SNP presented. The whole GWAS results are shown in Supplementary Fig. 1. The inset of the Manhattan plot on the left of the figure shows a Q-Q plot, with expected P values on the x-axis and observed P values on the y-axis.